At the 73rd Colloid and Interface Chemistry Conference,
we presented “Structural Evaluation of Liposomes Prepared
by Polyvalent Alcohol Method Using Small-Angle X-ray Scattering (SAXS).”
2022/9/22
Liposomes are cell membrane-like capsules composed of biological components similar to the skin, and due to the high level of technology required for their development and production, they are primarily used in high-end cosmetics. In this study, we prepared liposomes using a method known as the polyvalent alcohol method and conducted various evaluations to clarify their structural characteristics.
As a result, we confirmed the formation of fine liposomes with a particle size of less than 100 nm and the characteristic of a single-layer membrane using transmission electron microscopy. In addition, a high correlation with particle size measurements obtained by dynamic light scattering was observed.
Traditionally, the industrial production of liposomes has required processing with high-pressure emulsifiers, and multilayered liposomes have been the norm. By utilizing the polyvalent alcohol method, we were able to prepare single-layer liposomes without the need for specialized manufacturing equipment and conducted structural evaluations of liposome aqueous solutions at various concentrations. We believe the findings from this study can lead to the assessment of novel properties of liposomes.
These research results were presented orally at the 73rd Colloid and Interface Chemistry Conference, held from September 20 to 22, 2022, at Hiroshima University in Hiroshima Prefecture. This study was conducted in collaboration with Nikko Chemicals Co., Ltd.
As a result, we confirmed the formation of fine liposomes with a particle size of less than 100 nm and the characteristic of a single-layer membrane using transmission electron microscopy. In addition, a high correlation with particle size measurements obtained by dynamic light scattering was observed.
Traditionally, the industrial production of liposomes has required processing with high-pressure emulsifiers, and multilayered liposomes have been the norm. By utilizing the polyvalent alcohol method, we were able to prepare single-layer liposomes without the need for specialized manufacturing equipment and conducted structural evaluations of liposome aqueous solutions at various concentrations. We believe the findings from this study can lead to the assessment of novel properties of liposomes.
These research results were presented orally at the 73rd Colloid and Interface Chemistry Conference, held from September 20 to 22, 2022, at Hiroshima University in Hiroshima Prefecture. This study was conducted in collaboration with Nikko Chemicals Co., Ltd.