At the 89th SCCJ Research Conference, we presented “Preparation of Size-Controlled Liposomes Using the Polyvalent Alcohol Method.”
2022/12/2
Liposomes are cell membrane-like capsules composed of biological components similar to the skin. Due to their high moisturizing power and pleasant texture, they have been increasingly applied to enhance the functional and sensory values of cosmetics. To elucidate the relationship between these benefits and liposome particle size, this study aimed to prepare size-controlled liposomes of identical composition by examining the preparation process of the polyvalent alcohol method.
As a result, we confirmed through dynamic light scattering that we could prepare liposome aqueous solutions with controlled particle sizes ranging from less than 100 nm to over 300 nm. Additionally, viscosity measurements indicated that larger particle sizes corresponded to higher viscosity.
Traditional size control of liposomes using high-pressure emulsifiers requires the use of auxiliary surfactants, which may affect the product’s sensory properties. However, by using the polyvalent alcohol method, we were able to control particle size while maintaining the same composition, allowing us to evaluate the sensory properties of different particle sizes. We believe that the findings from this study will help further clarify the characteristics of liposomes within fine particle size ranges and their interactions with the skin.
These research results were presented orally at the 89th SCCJ Research Conference, held on December 2, 2022, at Tower Hall Funabori in Tokyo. This study was conducted in collaboration with Nikko Chemicals Co., Ltd.
As a result, we confirmed through dynamic light scattering that we could prepare liposome aqueous solutions with controlled particle sizes ranging from less than 100 nm to over 300 nm. Additionally, viscosity measurements indicated that larger particle sizes corresponded to higher viscosity.
Traditional size control of liposomes using high-pressure emulsifiers requires the use of auxiliary surfactants, which may affect the product’s sensory properties. However, by using the polyvalent alcohol method, we were able to control particle size while maintaining the same composition, allowing us to evaluate the sensory properties of different particle sizes. We believe that the findings from this study will help further clarify the characteristics of liposomes within fine particle size ranges and their interactions with the skin.
These research results were presented orally at the 89th SCCJ Research Conference, held on December 2, 2022, at Tower Hall Funabori in Tokyo. This study was conducted in collaboration with Nikko Chemicals Co., Ltd.